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PARI
Pharma Presents Study Results of Sinus Delivery
and Inhaled Liposomal Ciclosporin A at European
Cystic Fibrosis Conference
MUNICH, GERMANY, JUNE 14, 2007 - PARI Pharma
will present in-vivo study results for their
PARI SINUS pulsating drug delivery system as
well as lung deposition and pharmacokinetic data
of their proprietary inhaled liposomal
Ciclosporin A formulation in lung transplant
patients at the European Cystic Fibrosis
Conference (ECFC) in Belek, Turkey this week.
Continuing their tradition of developing highly
advanced inhalation delivery platforms, PARI has
created a pulsating sinus drug delivery system
to target the upper respiratory tract. Study
results at ECFC will focus on visual deposition
results using dynamic 81mKr-gas ventilation
imaging.
In a separate poster presentation, study results
will be presented showing lung deposition and
pharmacokinetics of inhaled Ciclosporin A given
to 12 lung transplanted patients using PARI
Pharma's proprietary liposomal platform
technology delivered via a customized eFlow
electronic nebulizer. Inhaled Ciclosporin A is a
potential therapy for lung transplant patients
that is hoped to improve survival rates while
reducing side effects by targeting drug delivery
of a Ciclosporin A formulation with eFlow so
that lower doses of drug may be effective. Using
a vibrating membrane, eFlow can produce aerosols
with a very high density of active drug, a
precisely defined droplet size, and a high
proportion of respirable droplets delivered in
the shortest possible period of time.
About ECFC
The European Cystic Fibrosis Conference, held by
the European Cystic Fibrosis Society, focuses on
international advancements in the treatment of
cystic fibrosis. Cystic fibrosis is an inherited
chronic disease that affects the lungs and
digestive systems of an estimated 70,000
children and adults worldwide. Additional
information is available online at
www.europeancfconference.org.
About PARI Pharma
PARI Pharma develops aerosol delivery devices
and inhaled therapies. Based on PARI's 100-year
history working with aerosols, PARI Pharma
specializes in treatments for pulmonary and
nasal administration optimized to advanced
delivery platforms, such as eFlow.
Focusing on comprehensive inhalation therapy
development, including optimized nebulizer
formulations, analytics, and aerosol
characterization, PARI Pharma has several
clinical development programs ongoing, either
partnered or proprietary. PARI Pharma, a PARI
Medical Holding company, is located in Munich,
Germany, with a major presence in the United
States. Online at http://www.paripharma.com
Additional information is available by
contacting Kirsten Ayars at 805-452-7909 or
Geoff Hunziker at 831-372-3580.
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